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The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy
07:51

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Published on: June 1, 2019

Subareolar sentinel node biopsy for multiple breast cancers.

Rakhshanda Layeeque1, Ronda Henry-Tillman, Soheila Korourian

  • 1Department of Surgery, Arkansas Cancer Research Center, Central Arkansas Veterans Healthcare System, Little Rock, AR, USA.

American Journal of Surgery
|December 16, 2003
PubMed
Summary

Subareolar injection (SI) accurately identifies sentinel lymph nodes (SLN) in multiple breast cancers. This technique shows 100% sensitivity, offering a potential alternative to complete axillary dissection for these patients.

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Breast Cancer Research

Background:

  • Sentinel lymph node biopsy (SLNB) is typically limited to unifocal breast cancers due to potential drainage to multiple lymph nodes.
  • Multiple breast cancers (MC) present a challenge for accurate SLNB, potentially requiring more extensive surgical procedures.

Purpose of the Study:

  • To evaluate the efficacy of subareolar injection (SI) for accurately identifying sentinel lymph nodes (SLN) in patients with multiple breast cancers (MC).
  • To determine if SI-guided SLNB can be a reliable alternative to complete axillary dissection in MC patients.

Main Methods:

  • Prospective study involving subareolar injection (SI) of lymphazurin or technetium sulfur colloid in patients with MC.
  • Sentinel lymph nodes (SLN) were identified using SI, followed by complete axillary dissection to assess SLNB accuracy.

Main Results:

  • SLNs were successfully identified in 100% of the 40 patients with MC.
  • SLNB demonstrated 100% sensitivity and a 0% false-negative rate.
  • In 45% of patients, the SLN was the only node affected by cancer, suggesting potential avoidance of complete axillary dissection.

Conclusions:

  • Subareolar injection (SI) is a highly effective technique for sentinel lymph node biopsy (SLNB) in patients with multiple breast cancers (MC).
  • SI-guided SLNB offers a promising alternative to complete axillary dissection, improving accuracy and potentially reducing morbidity in MC management.