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Related Experiment Videos

Contact hypersensitivity to topical corticosteroids.

A D Burden1, M H Beck

  • 1Skin Hospital, Salford, U.K.

The British Journal of Dermatology
|November 1, 1992
PubMed
Summary
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Topical corticosteroids are common causes of allergic contact dermatitis. Tixocortol pivalate (TP) is a valuable marker for steroid hypersensitivity, though further markers are needed for comprehensive screening.

Area of Science:

  • Dermatology
  • Allergology
  • Contact Dermatitis

Background:

  • Topical corticosteroids are increasingly identified as frequent contact sensitizers.
  • Corticosteroid hypersensitivity is a growing concern in dermatology.
  • Routine patch testing often includes evaluation for potential allergens.

Purpose of the Study:

  • To assess the prevalence of corticosteroid hypersensitivity in patients undergoing patch testing.
  • To evaluate the efficacy of tixocortol pivalate (TP) as a marker for steroid allergy.
  • To identify common steroid sensitizers and patterns of cross-reactivity.

Main Methods:

  • Patch testing was conducted on 2687 patients with tixocortol pivalate (TP).
  • An additional 528 patients were tested with a series of 18 different steroids.

Related Experiment Videos

  • Data collected between July 1988 and December 1991.

    • Main Results:

    • A 4.9% prevalence of corticosteroid hypersensitivity was detected.
    • Tixocortol pivalate (TP) identified 90.8% of positive corticosteroid allergy cases.
    • Hydrocortisone, budesonide, and hydrocortisone 17-butyrate were the most frequent sensitizers in the steroid series; 54% of these patients showed multiple steroid reactions.

    Conclusions:

    • Screening for steroid allergy should be integrated into standard patch testing protocols.
    • Tixocortol pivalate (TP) is a valuable marker for corticosteroid hypersensitivity, but not universally effective.
    • Further research is needed to identify additional markers for comprehensive steroid allergy detection.