[Serum concentration of leptin and resistin in girls during puberty]

The aim of this study was to find the link, if any between leptin, resistin and amount of adipose tissue in girls during puberty.

Forty six healthy girls aged 9, 8-15, 4 took part in this study, from which 12 were after menarche. Height, weight, body mass index, arm circumference and thickness of skin-fold were assessed. Serum concentrations of estradiol, FSH, LH, insulin, leptin and resistin were estimated.

As it was expected, girls before menarche were younger, smaller, lighter, had smaller BMI, arm circumference and serum concentration of sex hormones than those after menarche. No significant differences between skinfold thickness on abdomen and at triceps site as well as between serum leptin (4, 88 +/- 4, 16 ng/ml in girls before menarche, 6.56 +/- 5.15 ng/ml), were found. The concentrations of insulin occurred to be similar, too. No correlations between serum resistin and insulin concentration as well as between serum resitin and leptin concentration were noticed, either. The existence of high positive correlations between leptin concentration and skin-fold thickness was confirmed but the correlation between resistin concentration and skinfold thickness was not proved. Interdependences between the serum concentrations of leptin, resistin and sex hormones were not found, either.