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Updated: Feb 9, 2026

Purification and Reconstitution of TRPV1 for Spectroscopic Analysis
Published on: July 3, 2018
Anthracycline gels. II. Spectroscopic study on doxorubicin-lecithin association products
M Giomini1, A M Giuliani, M Giustini
1Dipartimento di Chimica, Università La Sapienza, Rome, Italy.
Abstract:
Thixotropic and thermally reversible gels have been prepared from doxorubicin-lecithin association products (DL12) by addition of salts to their aqueous solutions. The gel formation and the melting profiles have been followed by several spectroscopic techniques (1H NMR, UV-Vis, Circular Dichroism). The transition temperatures increase as the concentration of both the salt and the DL12 is increased, suggesting a progressive closer approach of the gel forming species. The process of the gel formation is cooperative and causes immobilization of the doxorubicin molecules of DL12.
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