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Updated: Aug 29, 2026

Isolating Free Carbenes, their Mixed Dimers and Organic Radicals
Published on: April 19, 2019
Strategies for heterocyclic construction via novel multicomponent reactions based on isocyanides and nucleophilic
Vijay Nair1, C Rajesh, A U Vinod
1Organic Chemistry Division, Regional Research Laboratory (CSIR), Trivandrum 695 019, India. vijaynair_2001@yahoo.com
Abstract:
This Account focuses mainly on our recent endeavors in the area of multicomponent reactions (MCRs) involving zwitterionic species generated by the addition of isocyanides and nucleophilic carbenes such as dimethoxycarbene and N-heterocyclic carbenes to activated alkynes. The strategy employed encompasses the interception of 1:1 zwitterionic species, generated in situ with a wide range of electrophiles. The new MCRs developed offer an efficient and convenient entry into several heterocycles of biological and synthetic importance.
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