Related Experiment Video
Updated: Aug 29, 2026

Preparation of Acute Slices from Dorsal Hippocampus for Whole-Cell Recording and Neuronal Reconstruction in the Dentate Gyrus of Adult Mice
Published on: April 3, 2021
Localization of function within the dorsal hippocampus: the role of the CA3 subregion in paired-associate learning
Paul E Gilbert1, Raymond P Kesner
1Department of Head and Neck Surgery, University of California, San Diego, USA.
Abstract:
Computational models and electrophysiological data suggest that the CA3 subregion of the hippocampus supports the formation of arbitrary associations; however, no behavioral studies have been conducted to test this hypothesis. Rats with neurotoxin-induced lesions of dorsal dentate gyrus (DG), CA3, or CA1 were tested on object-place and odor-place paired-associate tasks to test whether the mechanism that supports paired-associate learning is localized to the CA3 subregion of the dorsal hippocampus or whether all hippocampal subregions contribute to paired-associate learning. The data indicate that rats with DG or CA1 lesions learned the tasks as well as controls; however, CA3-lesioned rats were impaired in learning the tasks. Thus, the CA3 subregion of the dorsal hippocampus contains a mechanism to support paired-associate learning.
More Related Videos
Related Concept Videos
Role of Hippocampus in Memory
Role of Amygdala in Memory
One of the...
Higher Mental Functions of Brain: Learning and Memory
Olfaction
The olfactory receptors are embedded in the cilia of the...
Association Areas of the Cortex
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Associative Learning
Classical conditioning, also known...

