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Lateralized lexical decision in schizophrenia: hemispheric specialization and interhemispheric lexicality priming
Katherine L Narr1, Michael F Green, Linda Capetillo-Cunliffe
1Department of Neurology, University of California, Los Angeles, Los Angeles, CA 90095-1769, USA. narr@loni.ucla.edu
Journal of Abnormal Psychology
|December 17, 2003
Summary
Schizophrenia patients show impaired performance and error monitoring but maintain typical hemispheric specialization. Findings suggest increased automatic interhemispheric information transfer, not altered brain lateralization.
Area of Science:
- Cognitive Neuroscience
- Neuropsychology
- Psychiatry
Background:
- Existing research on left-hemisphere dysfunction and interhemispheric transfer in schizophrenia presents conflicting findings.
- Understanding brain lateralization and information processing is crucial for schizophrenia research.
Purpose of the Study:
- To investigate hemispheric specialization in word recognition and error monitoring.
- To assess interhemispheric transfer in individuals with schizophrenia using a unified paradigm.
- To clarify the nature of cognitive deficits in schizophrenia concerning brain lateralization.
Main Methods:
- Employed the lateralized lexical decision task (LLDT) in male, right-handed participants.
- Compared individuals with schizophrenia (n=34) against healthy controls (n=20).
- Analyzed performance, error monitoring, and interhemispheric priming effects.
Main Results:
- Schizophrenia patients exhibited overall poorer performance and impaired error monitoring compared to controls.
- Both groups demonstrated left-hemisphere superiority for lexical processing and right-hemisphere superiority for error monitoring.
- Patients uniquely displayed selective interhemispheric lexicality priming for accuracy.
Conclusions:
- Schizophrenia is associated with compromised monitoring functions.
- Findings indicate increased automatic interhemispheric information transfer in schizophrenia.
- There is no evidence of altered hemispheric specialization for language or error monitoring in schizophrenia.