Related Experiment Video
Updated: Aug 29, 2026

An Intact Pericardium Ischemic Rodent Model
Published on: September 2, 2021
Hepatic hydropericardium
Ting Kin Cheung1, William Tam, Dylan Bartholomeusz
1Department of Gastroenterology, Hepatology and General Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia. cheungtingkin@yahoo.com
Insights
This case report details a patient with hepatitis C and cirrhosis who developed recurrent pericardial effusions due to a connection between abdominal ascites and the pericardial sac. Liver transplantation resolved the effusions, highlighting a rare complication of advanced liver disease.
Area of Science:
- Cardiology
- Hepatology
- Gastroenterology
Background:
- Cirrhosis, a severe form of liver disease, can lead to complex fluid-related complications.
- Pericardial effusion, the buildup of fluid around the heart, can cause cardiac tamponade, a life-threatening condition.
Observation:
- A patient with chronic hepatitis C and cirrhosis presented with recurrent pericardial effusions and ascites.
- Radionuclide scans revealed a direct communication between the peritoneal and pericardial spaces.
- Initial treatments including pericardiocentesis and pericardial window formation provided only temporary relief.
Findings:
- The study reports the first case of pericardial effusion directly linked to cirrhotic ascites via a peritoneopericardial communication.
- Recurrent effusions persisted despite medical management and surgical intervention, underscoring the complexity of the condition.
Implications:
- This case highlights a rare but significant complication of advanced liver disease, emphasizing the need for considering peritoneopericardial fistulas in similar presentations.
- Successful orthotopic liver transplantation resolved the effusions, suggesting it as a definitive treatment for this specific complication.
- Understanding this pathway is crucial for managing complex fluid dynamics in patients with cirrhosis and ascites.
Abstract:
A 41-year-old man with chronic hepatitis C and cirrhosis presented with pericardial effusion and tamponade requiring pericardiocentesis. Nine liters of pericardial fluid was drained with complete resolution of his ascites. He represented with recurrent pericardial effusions despite salt restriction and diuretic therapy. Subsequent radionuclide scans demonstrated a direct connection between the peritoneal and pericardial spaces. A pericardial window was formed but despite this there was recurrence of pericardial effusion and pleural effusion. The patient underwent orthotopic liver transplantation 7 months later and no recurrence of pleural or pericardial effusion was observed following transplantation. We believe this is the first case report of pericardial effusion secondary to cirrhotic ascites and a communication between the peritoneal and pericardial cavities.
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