The role of dynamics in allosteric regulation
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Updated: Aug 28, 2026

Bio-layer Interferometry for Measuring Kinetics of Protein-protein Interactions and Allosteric Ligand Effects
Published on: February 18, 2014
Dorothee Kern1, Erik R P Zuiderweg
1Department of Biochemistry, Brandeis University, 415 South Street, Waltham, MA 02454-9110, USA. dkern@brandeis.edu
Abstract:
The biomolecular conformational changes often associated with allostery are, by definition, dynamic processes. Recent publications have disclosed the role of pre-existing equilibria of conformational substates in this process. In addition, the role of dynamics as an entropic carrier of free energy of allostery has been investigated. Recent work thus shows that dynamics is pivotal to allostery, and that it constitutes much more than just the move from the 'T'-state to the 'R'-state. Emerging computational studies have described the actual pathways of allosteric change.
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