Positive correlation between in vivo oxidized LDL and LDL immune complexes
Related Experiment Video
Updated: Aug 8, 2026
Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions
Published on: October 17, 2017
Hu Bing1, Junjun Wang, Chunni Zhang
1Department of Traditional Chinese Medicine, Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing 210002, China.
Objectives:
To investigate the possible relationship between oxidized low-density lipoprotein (ox-LDL) and LDL immune complexes (IC).
Methods:
Both LDL-IC and ox-LDL were detected by sandwich ELISA. The levels were also studied in 60 patients with coronary heart disease (CHD) and 50 control subjects.
Results:
Compared to controls, both the plasma ox-LDL concentrations (595.5 +/- 194.8 vs. 440.3 +/- 175.0 microg/l, P < 0.001) and LDL-IC levels (2.74 +/- 0.73 vs. 1.38 +/- 0.78 AU, P < 0.001) in the patients with CHD were significantly increased. The relationships between LDL-IC, ox-LDL levels, and other lipid parameters in all the studied subjects (n = 100) were analyzed. LDL-IC levels were positively correlated with TC, TG, LDL-C, lipoprotein(a) [Lp(a)], and apolipoprotein B (apoB) concentration, while negatively correlated with apoA1 concentration, respectively. Similarly, ox-LDL levels were also found positively correlated with TC, LDL-C, and apoB concentrations, respectively. Furthermore, a significantly positive correlation between ox-LDL and LDL-IC levels was found (r = 0.313, P < 0.005).
Conclusion:
In vivo oxidized LDL positively correlates with circulating levels of LDL immune complexes.
