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Positive correlation between in vivo oxidized LDL and LDL immune complexes
Hu Bing1, Junjun Wang, Chunni Zhang
1Department of Traditional Chinese Medicine, Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing 210002, China.
Objectives:
To investigate the possible relationship between oxidized low-density lipoprotein (ox-LDL) and LDL immune complexes (IC).
Methods:
Both LDL-IC and ox-LDL were detected by sandwich ELISA. The levels were also studied in 60 patients with coronary heart disease (CHD) and 50 control subjects.
Results:
Compared to controls, both the plasma ox-LDL concentrations (595.5 +/- 194.8 vs. 440.3 +/- 175.0 microg/l, P < 0.001) and LDL-IC levels (2.74 +/- 0.73 vs. 1.38 +/- 0.78 AU, P < 0.001) in the patients with CHD were significantly increased. The relationships between LDL-IC, ox-LDL levels, and other lipid parameters in all the studied subjects (n = 100) were analyzed. LDL-IC levels were positively correlated with TC, TG, LDL-C, lipoprotein(a) [Lp(a)], and apolipoprotein B (apoB) concentration, while negatively correlated with apoA1 concentration, respectively. Similarly, ox-LDL levels were also found positively correlated with TC, LDL-C, and apoB concentrations, respectively. Furthermore, a significantly positive correlation between ox-LDL and LDL-IC levels was found (r = 0.313, P < 0.005).
Conclusion:
In vivo oxidized LDL positively correlates with circulating levels of LDL immune complexes.
