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A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity
Published on: June 11, 2019
Spleen's relative growth in human fetuses
G F Ferreira1, R M Rega, C A Mandarim-de-Lacerda
1Department of Anatomy, State University of Rio de Janeiro (UERJ), Brazil.
Bulletin De L'Association Des Anatomistes
|June 1, 1992
Summary
Spleen weight in human fetuses grows significantly with gestational age, crown-rump length, and fetal weight. These findings establish spleen growth curves valuable for various medical fields.
Area of Science:
- Human fetal development
- Biometry
- Anatomy
Background:
- Spleen development is crucial for fetal health.
- Understanding spleen growth patterns aids in assessing fetal well-being.
Purpose of the Study:
- To analyze the allometric growth of spleen weight in human fetuses.
- To establish spleen weight growth curves correlated with fetal parameters.
Main Methods:
- Bivariate allometry was used to study spleen weight.
- Thirty human fetuses (16-36 weeks) were analyzed.
- Reduced Major Axis (RMA) regression was applied.
Main Results:
- Spleen weight showed statistically significant positive allometry relative to gestational age, crown-rump length, and fetal weight.
- Allometric coefficients (RMA) for spleen weight vs. fetal weight were 1.21 (second trimester), 1.73 (third trimester), and 1.65 (combined).
Conclusions:
- Statistically significant growth curves for fetal spleen weight were established.
- These growth curves are applicable in anatomy, forensic medicine, medical imagery, fetopathology, obstetrics, and pediatrics.
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