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Updated: Aug 19, 2026

Focus Formation: A Cell-based Assay to Determine the Oncogenic Potential of a Gene
Published on: December 31, 2014
Significance of c-Myc and Bcl-2 protein expression in nasopharyngeal carcinoma
Yongqiang Yu1, Weidong Dong, Xin Li
1Department of Otolaryngology, Beifang Hospital of Shenyang, 83 Wenhua Road, Shenhe District, Shenyang City, Liaoning Province, People's Republic of China 110015. chanpingwang@yahoo.ca
Objective:
To investigate the relationship between oncogene protein expression and nasopharyngeal carcinoma outcome.
Design:
Tumor samples from 51 patients with nasopharyngeal carcinoma were analyzed by immunohistochemical staining for expression of Bcl-2 and c-Myc protein before irradiation. Five-year follow-up data were available.
Results:
Thirty-one (61%) of 51 tumors expressed Bcl-2 protein, and 29 (57%) of 51 tumors expressed c-Myc protein. In the Bcl-2+ group, 20 (65%) and 19 (61%) of 31 patients experienced recurrence or died, respectively, whereas only 7 (35%) and 5 (25%) of 20 patients with Bcl-2- tumors did so. On the other hand, patients with c-Myc+ tumors had lower recurrence and death rates (38% [11/29] and 34% [10/29], respectively) than those with c-Myc- tumors (73% [16/22] and 64% [14/22], respectively). A statistically significant association was confirmed between Bcl-2 and c-Myc positivity and patient outcome.
Conclusion:
Expression of Bcl-2 and c-Myc protein seems to be a useful marker to reflect irradiation response and to predict illness condition and patient outcome.
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