Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cerebral hemodynamics during microgravity.

Taro Miyahara Gotoh1, Kunihiko Tanaka, Nobuhiro Fujiki

  • 1Department of Physiology, Gifu University School of Medicine.

Uchu Seibutsu Kagaku
|December 17, 2003
PubMed
Summary

Microgravity alters intracranial pressure (ICP) and cerebral perfusion pressure (CPP) in head-up positions, indicating increased cerebral blood flow resistance. These findings shed light on space adaptation syndrome mechanisms.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of microgravity and lunar gravity on murine skeletal and immune systems during space travel.

Scientific reports·2024
Same author

Weak magnetic vestibular stimulation decreases postural sway.

Neuroscience letters·2024
Same author

Remimazolam and Remifentanil Anesthetics for an Adolescent Patient with Stiff-Person Syndrome: A Case Report.

A&A practice·2024
Same author

Optimization of Sulfide Annealing Conditions for Ag<sub>8</sub>SnS<sub>6</sub> Thin Films.

Materials (Basel, Switzerland)·2023
Same author

Lunar gravity prevents skeletal muscle atrophy but not myofiber type shift in mice.

Communications biology·2023
Same author

Repeated activation of C1 neurons in medulla oblongata decreases anti-inflammatory effect via the hypofunction of the adrenal gland adrenergic response.

Brain, behavior, and immunity·2023

Area of Science:

  • Physiology
  • Space Medicine
  • Neuroscience

Background:

  • Space adaptation syndrome is linked to cephalad fluid shifts causing increased intracranial pressure (ICP).
  • Understanding intracranial pressure dynamics is crucial for astronaut health during spaceflight.

Purpose of the Study:

  • To investigate the effects of simulated microgravity on ICP, arterial pressure, and cerebral flow velocity (CFV) in different body positions.
  • To analyze the relationship between cerebral perfusion pressure (CPP) and CFV under simulated microgravity conditions.

Main Methods:

  • Anesthetized rats were subjected to 4.5 seconds of microgravity via free drop.
  • Intracranial pressure (ICP), aortic pressure, and cerebral flow velocity (CFV) were measured in horizontal prone (Flat) and 30-degree head-up (HU) positions.

Related Experiment Videos

  • Cerebral perfusion pressure (CPP) and the CPP-CFV relationship were calculated.

    • Main Results:

    • In the head-up (HU) position, ICP, arterial pressure at eye level (APeye), and CPP significantly increased during microgravity.
    • Cerebral flow velocity (CFV) did not significantly change in either position.
    • The slope of the CPP-CFV relationship decreased in the HU position, suggesting increased cerebral vascular resistance.

    Conclusions:

    • Simulated microgravity in a head-up position elevates ICP and CPP, potentially contributing to space adaptation syndrome.
    • The observed increase in cerebral vascular resistance indicates altered cerebral blood flow regulation during microgravity.
    • Cerebral autoregulation mechanisms may be involved in maintaining cerebral blood flow during these conditions.