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[The effect of topical ascorbic acid application on the healing of rat tympanic membrane perforations]
Ozgür Yiğit1, Uğur Cinar, Berna Uslu Coşkun
1Department of Otolaryngology (2. KBB Kliniği), Sişli Etfal Training Hospital, Istanbul, Turkey.
Objectives:
We investigated the effect of topical administration of ascorbic acid on the healing process of tympanic membrane perforations in rats.
Design And Methods:
Thermal myringotomy was induced in both ears of 22 albino rats. The right and left ears were assigned to topical applications of ascorbic acid and saline solution, respectively. The same procedure was performed after 48 hours. Perforations were examined daily by otomicroscopy and healing periods were determined. For histopathologic examination, a single rat in which closure of the tympanic membranes was not completed was sacrificed on days 5, 7, 10, and 12. Data were analyzed with the use of the Student's t-test.
Results:
The mean durations of healing in the right and left ears were 7.6 and 8.3 days, respectively. No significant differences were found between the applications of ascorbic acid and saline solution with regard to the duration of closure and histopathologic healing criteria.
Conclusion:
Our data suggest that topical application of ascorbic acid have no beneficial effect on the healing of rat tympanic membrane perforations.
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