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Chronic ulcerative stomatitis: clinical, histopathologic, and immunopathologic findings
Lynn W Solomon1, Alfredo Aguirre, Mirdza Neiders
1Department of Oral Diagnostic Sciences, School of Dental Medicine, State University of New York, Buffalo 14214, USA. lsolomon@buffalo.edu
Summary
Chronic ulcerative stomatitis (CUS) is a rare oral condition. Unique IgG autoantibodies targeting stratified epithelial specific (SES) antinuclear antibodies (ANA) are key diagnostic markers, guiding effective hydroxychloroquine treatment.
Area of Science:
- Immunodermatology
- Oral Medicine
- Autoimmune Diseases
Background:
- Chronic ulcerative stomatitis (CUS) is a mucocutaneous condition.
- Oral lesions can mimic erosive oral lichen planus.
- Distinguishing CUS is crucial for effective treatment.
Observation:
- CUS presents with erosive or ulcerative oral mucosal lesions.
- Direct immunofluorescence shows IgG bound to keratinocyte nuclei (SES-ANA pattern).
- Circulating SES-ANA detected in patient sera via indirect immunofluorescence.
Findings:
- Three CUS cases detailed with clinical and immunopathologic findings.
- Autoantibody recognition of CUS antigen confirmed via Western blot.
- CUS can be refractory to topical corticosteroids.
Implications:
- SES-ANA pattern is a unique diagnostic biomarker for CUS.
- Hydroxychloroquine demonstrates favorable clinical responses in CUS.
- Early diagnosis and targeted therapy improve patient outcomes.