Related Experiment Videos
Survivin expression in oral squamous cell carcinoma
L Lo Muzio1, G Pannone, S Staibano
1Institute of Dental Sciences, Faculty of Medicine, University of Ancona, Ancona, Italy. llomuzio@tin.it
British Journal of Cancer
|December 17, 2003
Summary
Survivin, an apoptosis inhibitor, is highly expressed in oral squamous cell carcinoma (SCC) and its metastases. High survivin expression in oral SCC patients indicates a poorer prognosis, suggesting its role in aggressive tumor phenotypes.
Area of Science:
- Oncology
- Molecular Biology
- Pathology
Background:
- Oral squamous cell carcinoma (SCC) is a significant global health concern.
- Apoptosis inhibitors, such as survivin, play a role in cancer progression.
- Understanding biomarkers for SCC aggressiveness is crucial for patient outcomes.
Purpose of the Study:
- To investigate survivin expression in oral SCC.
- To correlate survivin expression with clinicopathological features.
- To evaluate the prognostic significance of survivin in oral SCC.
Main Methods:
- Immunohistochemistry and Western blotting were used to analyze survivin expression.
- 110 oral SCC cases, including metastatic lesions, were studied.
- Expression levels were correlated with patient age, sex, tumor size, differentiation, and survival.
Main Results:
- Survivin was expressed in 82.7% of oral SCC cases and 100% of metastases.
- Normal oral epithelium did not express survivin.
- Low survivin expression correlated with significantly better survival rates (P<0.05).
Conclusions:
- Survivin is a potential biomarker for oral SCC.
- Increased survivin expression may indicate a more aggressive tumor phenotype.
- Survivin expression can help identify patients with a poorer prognosis in oral SCC.