Related Experiment Video
Updated: Aug 17, 2026

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa
Published on: October 22, 2015
[Adolescent-onset anorexia nervosa]
B W Feitlich1, M A Larino, A Cobelo
1Universidade de São Paulo (USP), São Paulo, SP, Brazil.
Abstract:
OBJECTIVE: This paper is a review on the topic of adolescent-onset anorexia nervosa. According to the literature, this disorder presents high morbidity and mortality, with increasing incidence over the last decades, thus enhancing the importance of scientific investigation on the subject. METHODS: The authors performed a non-systematic review of the related literature and also reported their clinical experience. RESULTS: Age and gender are important risk factors. The peak of incidence occurs in adolescence and the prevalence is 9 times higher in females. It was initially believed that anorexia nervosa manifested itself only in higher socioeconomic levels, which are more highly exposed to the demands of western beauty standards. More recent studies have identified similar incidence of this disorder also in lower socioeconomic levels, rural areas and Asian communities. The clinical features are: refusal to maintain weight at or above a minimal normal weight for age; high, intense fear of gaining weight or becoming fat, even though underweight; disturbance in the way of experiencing one s body weight or shape, and amenorrhea. The most common physical complications are similar to those of chronic malnutrition and depression is the main comorbidity. CONCLUSIONS: Treatment should be multidisciplinary, taking into account the plurality of etiological factors. Family therapy plays an important role, particularly when this disorder manifests itself during adolescence.
Related Concept Videos
Obesity
Cognitive Development During Adolescence
Erikson's Theory on Socioemotional Development during Adolescence
Anorexia Nervosa
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
Bulimia Nervosa
Binge Eating Disorders

