Collective behaviour of crown channels
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Updated: Aug 29, 2026

Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells
Published on: July 16, 2013
Viksita Vijayvergiya1, Debasish Bose, Paramita Ghosh
1Department of Biophysics, University of Delhi South Campus, 110021 New Delhi, India.
Abstract:
Collective behaviour of a crown ether channel, bis[(benzo-15-crown-5)-15- yl methyl] pimelate, in a planar lipid bilayer membrane has been studied through electrophysiological methods. A characteristic feature of these channels is their sequential opening, indicated by a uniform stepwise increase in the multi-channel current. The experimental results show that there are three modes of relaxation, of which the slowest one is attributed to the channel-channel interaction. The latter varies with the number of channels incorporated in the bilayer membrane, leading to the interpretation that crown channels behave cooperatively.
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