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Nodular scleroderma: case report and literature review
Leander Cannick1, Glenn Douglas, Scott Crater
1Department of Internal Medicine, Medical University of South Carolina, 96 Jonathan Lucas Street, Charleston, SC 29425, USA.
The Journal of Rheumatology
|December 17, 2003
Summary
Nodular scleroderma (SSc) is a rare variant presenting as keloid-like lesions. While osteoarthritis (OA) was noted in one case, it
Area of Science:
- Dermatology
- Rheumatology
- Pathology
Background:
- Scleroderma (SSc) is a complex autoimmune disease characterized by fibrosis, vascular abnormalities, and immune system dysfunction.
- A rare variant, nodular SSc, presents with distinct skin lesions resembling keloids.
- The association between nodular SSc and osteoarthritis (OA) is not well-established.
Purpose of the Study:
- To detail a unique case of nodular scleroderma (SSc) with keloidal nodules and early-onset osteoarthritis (OA).
- To compile and analyze clinical and serological data from similar reported cases of nodular SSc.
Main Methods:
- A MEDLINE literature review was conducted for cases of nodular SSc reported between 1966 and 2002.
- Clinical and diagnostic data from 13 previously reported cases were summarized.
- A detailed case report of a 40-year-old African-American male with localized SSc, keloidal nodules, and hip OA is presented.
Main Results:
- A total of 14 cases (13 from literature + 1 current case) of nodular SSc were analyzed.
- Diagnosis in all cases was confirmed by skin biopsy showing keloid (nodule) formation.
- Common SSc manifestations included arthralgias, sclerodactyly, and Raynaud's phenomenon; OA was not a typical feature.
Conclusions:
- Nodular SSc is an uncommon presentation of scleroderma characterized by keloid-like skin lesions.
- Osteoarthritis, as observed in the presented case, is not considered a typical clinical feature of nodular SSc.