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O/w dispersions development containing liquid crystals
R C Massaro1, M S Zabagli, C R Souza
1Faculty of Pharmaceutical Sciences of Ribeirão Preto, USP, Technology of Cosmetics, Brasile.
Bollettino Chimico Farmaceutico
|December 18, 2003
Summary
Liquid crystals, an intermediate state between solid and liquid, show potential in cosmetic vehicles for controlled drug delivery and enhanced skin hydration. These mesomorphous phase formulations were found to be stable and suitable for cosmetic applications.
Area of Science:
- Materials Science
- Cosmetic Science
- Physical Chemistry
Background:
- Liquid crystals represent a mesomorphous phase with properties between solid and liquid states.
- This phase offers potential for encapsulation and controlled release applications.
- Its use in cosmetic vehicles could enhance drug delivery and skin hydration.
Purpose of the Study:
- To investigate the potential of liquid crystals in novel cosmetic vehicle formulations.
- To evaluate the stability and rheological properties of these liquid crystal-based emulsions.
Main Methods:
- Formulations were developed using vegetable oils, mineral oil, phosphoric ester surfactants, and distilled water.
- Physicochemical stability was assessed through pH, conductivity, centrifugation, and thermal stress tests.
- Accelerated stability was evaluated via cold-hot cycles, and crystalline phase confirmed by polarized microscopy; rheology was tested before and after aging.
Main Results:
- Stable liquid crystal formulations were successfully developed.
- Physicochemical and accelerated stability tests indicated formulation resilience.
- Rheological properties were analyzed for both freshly prepared and aged samples.
Conclusions:
- Liquid crystals demonstrate promise as a functional component in cosmetic vehicles.
- The developed formulations exhibit stability suitable for cosmetic applications.
- Further investigation into their controlled release and skin hydration benefits is warranted.