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Updated: Aug 29, 2026

Establishment of a Rat Model for Intrauterine Adhesions via Dual Injury: Curettage and Infection
Published on: October 3, 2025
[Unavoidable surgical intervention in two women with severe actinomycosis during IUD use]
L A Bergenhenegouwen1, H H de Haan, E S Sijbrandij
1Afd. Gynaecologie en Verloskunde, Isala Klinieken, locatie Sophia, Postbus 10.400, 8000 GK Zwolle. lesterbhg@yahoo.com
Abstract:
Extensive abdominal infections with Actinomyces were diagnosed in two women aged 35 and 33 years respectively, who suffered from the nonspecific symptoms fever and abdominal pain. These infections occur more often in women with an intrauterine device. Development of an abdominal mass with ureter or bowel obstruction may cause hydronephrosis and mechanical ileus. The patients underwent a laparotomy and a double-J catheter was inserted, which could be removed later on (temporary stoma). Treatment included high-dose penicillin i.v. followed by oral amoxicillin. Both patients recovered. It may be difficult to establish this diagnosis: the first patient was diagnosed by histopathological examination, in the second Actinomyces had been found in a routine cervical smear a few years earlier.
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