Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rethinking the toxic methanol level.

M A Kostic1, R C Dart

  • 1Rocky Mountain Poison and Drug Center, Denver Health Authority, Denver, Colorado 80230, USA. makostic@mar.med.navy.mil

Journal of Toxicology. Clinical Toxicology
|December 18, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Non-medical use of loperamide in the UK and the USA.

QJM : monthly journal of the Association of Physicians·2019
Same author

Trends in intentional abuse or misuse of benzodiazepines and opioid analgesics and the associated mortality reported to poison centers across the United States from 2000 to 2014.

Clinical toxicology (Philadelphia, Pa.)·2018
Same author

The effect of an abuse-deterrent opioid formulation (OxyContin) on opioid abuse-related outcomes in the postmarketing setting.

Clinical pharmacology and therapeutics·2016
Same author

A model to improve the accuracy of US Poison Center data collection.

Clinical toxicology (Philadelphia, Pa.)·2014
Same author

A single-arm clinical trial of a 48-hour intravenous N-acetylcysteine protocol for treatment of acetaminophen poisoning.

Clinical toxicology (Philadelphia, Pa.)·2014
Same author

The effects of paracetamol (acetaminophen) on hepatic tests in patients who chronically abuse alcohol - a randomized study.

Alimentary pharmacology & therapeutics·2010
Same journal

Ingestion of high-dose buprenorphine by a 4 year-old child.

Journal of toxicology. Clinical toxicology·2005
Same journal

A reassessment of topical organic phosphorus insecticide exposures and permanent paralysis.

Journal of toxicology. Clinical toxicology·2005
Same journal

Methamphetamine toxicity secondary to intravaginal body stuffing.

Journal of toxicology. Clinical toxicology·2005
Same journal

Duodenal perforation after ibuprofen overdose.

Journal of toxicology. Clinical toxicology·2005
Same journal

Delayed dystonia following pimozide overdose in a child.

Journal of toxicology. Clinical toxicology·2005
Same journal

Pattern of acute poisonings in Mashhad, Iran 1993-2000.

Journal of toxicology. Clinical toxicology·2005
See all related articles

Current methanol poisoning guidelines suggest treatment at 20 mg/dL, but this study found no evidence to support this early threshold. A blood methanol level of 126 mg/dL was the lowest associated with acidosis in early-presenting patients.

Area of Science:

  • Toxicology
  • Emergency Medicine
  • Clinical Chemistry

Background:

  • Current methanol poisoning treatment guidelines rely on limited data and expert opinion.
  • The established threshold for treatment is a blood methanol level of ≥20 mg/dL in nonacidotic patients.
  • The timing of methanol exposure and its impact on treatment thresholds are not well-defined.

Purpose of the Study:

  • To evaluate the applicability of the 20 mg/dL treatment threshold for methanol poisoning.
  • To analyze early blood methanol concentrations in nonacidotic patients presenting within 6 hours of ingestion.

Main Methods:

  • Systematic review of published literature (MEDLINE, EMBASE) and poison center data.
  • Inclusion criteria: known methanol exposure time, acid-base status, blood methanol, and blood ethanol (if nonacidotic).

Related Experiment Videos

  • Abstraction of 372 articles, with 70 meeting inclusion criteria (173 patients).

    • Main Results:

    • Only 22 patients presented within 6 hours with early methanol levels.
    • Acidosis was observed only at blood methanol levels ≥126 mg/dL.
    • One infant with an early level of 46 mg/dL treated with folate alone did not develop acidosis.

    Conclusions:

    • Existing data are insufficient to support the 20 mg/dL treatment threshold for early-presenting, nonacidotic methanol poisoning patients.
    • The lowest early blood methanol level associated with acidosis was 126 mg/dL.
    • Further prospective studies are needed to guide management, including the potential for withholding antidotal therapy or dialysis.