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Increased plasma thioredoxin in patients with acute myocardial infarction

Hirofumi Soejima1, Hisakazu Suefuji, Shinzo Miyamoto

  • 1Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Honjo, Kumamoto, Japan. yuuki@gpo.kumamoto-u.ac.jp

Clinical Cardiology
|December 18, 2003
PubMed

Insights

Plasma thioredoxin levels are elevated in patients with acute myocardial infarction (AMI). Higher levels indicate a risk for failed coronary reperfusion therapy in AMI patients.

Area of Science:

  • Biochemistry
  • Cardiology
  • Biomarkers

Background:

  • Thioredoxin is a key biomarker for oxidative stress.
  • Elevated thioredoxin levels are implicated in various cardiovascular conditions.

Purpose of the Study:

  • To investigate elevated thioredoxin levels in acute myocardial infarction (AMI) patients.
  • To assess the association between thioredoxin levels and coronary reperfusion outcomes.

Main Methods:

  • Plasma thioredoxin levels were measured in 51 AMI patients, 30 stable exertional angina (SEA) patients, and 30 chest pain syndrome (CPS) patients.
  • Sampling occurred at multiple time points for AMI patients and upon admission for SEA and CPS patients.

Main Results:

  • AMI patients exhibited higher admission plasma thioredoxin levels compared to SEA and CPS groups.
  • Thioredoxin levels decreased within 12 hours in AMI patients but remained elevated compared to SEA.
  • Higher admission thioredoxin levels independently predicted failed emergent reperfusion therapy in AMI.

Conclusions:

  • Plasma thioredoxin is elevated in AMI patients.
  • Elevated thioredoxin levels may serve as a predictive marker for failed coronary reperfusion in AMI.
Abstract

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