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N-terminal-pro-B-type natriuretic peptide (NT-pro-BNP) in different thyroid function states
Marianne Schultz1, Jens Faber, Caroline Kistorp
1Department of Cardiology and Endocrinology E, Frederiksberg University Hospital, Frederiksberg, Denmark.
Clinical Endocrinology
|December 18, 2003
Summary
Thyroid function significantly impacts N-terminal B-type natriuretic peptide (NT-pro-BNP) levels. Thyroid hormones directly influence NT-pro-BNP, highlighting the importance of thyroid health in cardiac biomarker interpretation.
Area of Science:
- Endocrinology
- Cardiology
- Biomarkers
Background:
- N-terminal B-type natriuretic peptide (NT-pro-BNP) is a cardiac biomarker elevated in heart failure.
- Thyroid dysfunction is common and can affect cardiovascular function.
Purpose of the Study:
- To investigate the relationship between thyroid function and serum NT-pro-BNP levels.
- To determine if thyroid hormones directly influence NT-pro-BNP.
Main Methods:
- Evaluated patients with overt and subclinical thyroid disease (hypothyroidism and hyperthyroidism).
- Measured serum NT-pro-BNP, thyroid hormones (free T4, free T3), and cardiac output before and after treatment.
- Utilized impedance cardiography for cardiac output measurements.
Main Results:
- NT-pro-BNP levels were significantly higher in hyperthyroid patients compared to hypothyroid patients (30 vs. 7 pmol/l).
- Serum NT-pro-BNP levels showed a strong correlation with thyroid function (free T4 estimate: r = 0.52).
- Treatment normalized NT-pro-BNP levels, with increases in hypothyroid and decreases in hyperthyroid groups. Free T4 and free T3 were independently associated with NT-pro-BNP, not cardiac output or heart rate.
Conclusions:
- Serum NT-pro-BNP levels are demonstrably influenced by thyroid function.
- Thyroid hormones appear to have a direct stimulatory effect on NT-pro-BNP secretion.