Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immune biasing by helminth glycans.

Paul G Thomas1, Donald A Harn

  • 1Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA.

Cellular Microbiology
|December 18, 2003
PubMed
Summary

Helminth parasites use specific glycans to activate immune cells, promoting anti-inflammatory and Th2 responses. This mechanism involves immune cell interaction and antigen-presenting cell maturation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

HLHRUXO: A prospective trial of a ruxolitinib-containing regimen for children with hemophagocytic lymphohistiocytosis.

Blood advances·2026
Same author

IL4i1 activity generates oncometabolites that rescue neuroblastoma cells from oxidative death.

Cell reports·2026
Same author

Highly focused human CD8+ T-cell response in the lower airways during acute influenza infection.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same author

Rational engineering of the P5 TRS-mimic site and REP78/68 start codon yields promoter variants that improve rAAV purity while maintaining high titers.

Molecular therapy. Advances·2026
Same author

One-step generation of T-cell receptor knock-in mice in the TCRβ locus.

The EMBO journal·2026
Same author

High-dimensional multiomics reveals perturbations to IL-6/IL-6R axis and RUNX3 in CD4<sup>+</sup> T cells during third-trimester pregnancy.

Clinical & translational immunology·2026

Area of Science:

  • Immunology
  • Parasitology
  • Glycobiology

Background:

  • Helminth parasites are known to induce T helper 2 (Th2) immune responses.
  • Emerging evidence highlights the role of helminth-expressed glycans in modulating host immunity, leading to anti-inflammatory effects and Th2 polarization.

Purpose of the Study:

  • To review the biology of immunomodulatory glycans in helminths.
  • To explore interactions between helminth glycans and host immune cells, including cytokine, chemokine, and antibody production.
  • To discuss glycan-binding receptors and mechanisms underlying anti-inflammatory and Th2-biasing responses.

Main Methods:

  • Literature review of studies on helminth glycans and host immune responses.
  • Analysis of known mechanisms of glycan-mediated immune modulation.
  • Discussion of cell surface receptors and signaling pathways involved.

Main Results:

  • Helminth glycans are key drivers of anti-inflammatory and Th2 immune responses.
  • Specific helminth glycans activate immune cells, including antigen-presenting cells, leading to Type 2 dendritic cell maturation.
  • Mechanisms involve interactions with host cell surface receptors and modulation of cytokine/chemokine production.

Conclusions:

  • Helminth glycans represent a significant mechanism for immune evasion and modulation.
  • Understanding these interactions offers potential for therapeutic strategies targeting immune responses.

Related Experiment Videos