Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diaphragm motion affects flow patterns in an artificial heart.

Pramote Hochareon1, Keefe B Manning, Arnold A Fontaine

  • 1Department of Bioengineering and Applied Research Laboratory, Artificial Heart Laboratory, The Pennsylvania State University, University Park, PA 16802, USA.

Artificial Organs
|December 18, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Red Blood Cell Deformation in a Microfluidic Sudden Expansion at Supraphysiological Strain Rates.

Biophysical journal·2026
Same author

Endothelial Surface Glycocalyx in Vascular Functions and Diseases.

Advances in experimental medicine and biology·2026
Same author

Mechanical compaction alters microstructural and magnetic resonance imaging properties of acute ischemic stroke clots.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same author

Computational fluid dynamics assessment of altered hemodynamics in the Circle of Willis during acute ischemic stroke and the impact of cerebral collateral development.

Biomechanics and modeling in mechanobiology·2026
Same author

Modeling Red Blood Cell Deformation at Supraphysiological Strain Rates Using a Droplet Framework.

Annals of biomedical engineering·2026
Same author

Computational Modeling of Flow in an in Vitro Cerebrovascular Model Under Pulsatile Conditions with Experimental Validation.

Cardiovascular engineering and technology·2025

Diaphragm motion in sac-driven artificial hearts significantly impacts blood flow and pump efficiency. Nonuniform, wave-like diaphragm opening can impede inflow and affect performance.

Area of Science:

  • Biomedical Engineering
  • Fluid Dynamics
  • Medical Devices

Background:

  • Sac-driven artificial hearts rely on diaphragm motion for proper function.
  • Inaccurate diaphragm motion can lead to reduced pump output and thrombus formation.
  • Simulating in vivo sac motion is crucial for laboratory studies of artificial hearts.

Purpose of the Study:

  • To investigate the relationship between diaphragm motion and chamber flow characteristics in a Penn State artificial heart.
  • To understand how diaphragm dynamics influence inflow during the filling phase.
  • To assess the impact of altered operating conditions on diaphragm motion.

Main Methods:

  • Utilized flow visualization techniques during in vitro experimentation.
  • Employed high-speed videography to record chamber flow patterns and diaphragm motion.

Related Experiment Videos

  • Quantified diaphragm motion by tracking surface points and analyzing trajectory alignment.

    • Main Results:

    • Diaphragm motion was found to be nonuniform under most tested conditions.
    • The diaphragm typically opened in a wave-like pattern from the bottom toward the ports.
    • This observed motion pattern mimics that of clinical blood sacs in devices like the Lionheart LVAD.

    Conclusions:

    • Diaphragm motion significantly influences artificial heart hemodynamics.
    • Nonuniform diaphragm opening can negatively affect pump performance.
    • Accurate simulation of in vivo diaphragm dynamics is essential for reliable artificial heart research.