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Hypertension and nephropathy

George L Bakris1

  • 1Hypertension Clinical Research Center, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, USA.

The American Journal of Medicine
|December 18, 2003
PubMed

Insights

Many patients with hypertension and diabetes struggle to control blood pressure. Thiazolidinediones (TZDs) show promise in improving insulin resistance and vascular health, potentially reducing complications.

Area of Science:

  • Cardiology
  • Endocrinology
  • Nephrology

Background:

  • Hypertension and diabetes mellitus significantly increase cardiovascular and renal complication risks.
  • Most patients with both conditions do not achieve target systolic blood pressure (<130 mm Hg).
  • Renin-angiotensin system inhibitors and diuretics may help reduce blood pressure and slow nephropathy progression.

Purpose of the Study:

  • To explore the role of thiazolidinediones (TZDs) in managing hypertension and diabetes.
  • To investigate the vascular benefits of TZDs in type 2 diabetes patients.
  • To assess the impact of TZDs on glucose control, microalbuminuria, and hypertension.

Main Methods:

  • Review of recent studies on thiazolidinediones (TZDs) in type 2 diabetes.
  • Analysis of TZD effects on insulin resistance, vascular function, and blood pressure.
  • Examination of TZD association with microalbuminuria and hypertension development.

Main Results:

  • TZDs improve insulin resistance and offer vascular benefits like vasorelaxation and reduced inflammation.
  • These vascular effects are linked to blood pressure reduction and microalbuminuria prevention.
  • Early TZD use may aid glucose control and mitigate microalbuminuria and hypertension.

Conclusions:

  • TZDs demonstrate potential benefits for patients with type 2 diabetes and hypertension.
  • Their use may improve glycemic control and reduce cardiovascular and renal complications.
  • Further research supports TZDs as a valuable therapeutic option in this patient group.

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