Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Surface morphology of CD34+ cells under atomic force microscope].

Long-jiang Yang1, Fan-yi Meng, Mei-li Liu

  • 1Department of Hematology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.

Di 1 Jun Yi Da Xue Xue Bao = Academic Journal of the First Medical College of PLA
|December 18, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The near-zero-magnetic field alters microbial community structure and ecological functions in mangroves.

ISME communications·2026
Same author

Risk factors associated with false-positive fecal immunochemical test results in colorectal cancer screening.

Scientific reports·2026
Same author

Total marrow irradiation as part of autologous stem cell transplantation for patients with multiple myeloma.

Annals of hematology·2025
Same author

Phase-modulated Airy beam generation by a leaky-wave structure.

Optics letters·2024
Same author

Complex-Amplitude Programmable Versatile Metasurface Platform Driven by Guided Wave.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2024
Same author

Low-cost laser cutting fabricated all-metallic metamaterial near-field focusing lens.

Heliyon·2023

Normal CD34(+) cells exhibit a rougher surface compared to M2b leukemia cells, a difference not visible under optical microscopy but detectable with atomic force microscopy (AFM). This finding highlights AFM

Area of Science:

  • Hematology
  • Cell Biology
  • Biophysics

Context:

  • CD34(+) cells are crucial hematopoietic stem and progenitor cells.
  • Leukemia, particularly M2b subtype, involves abnormal myeloid cell proliferation.
  • Understanding cell surface morphology can offer insights into cellular function and disease states.

Purpose:

  • To investigate and compare the surface morphology and structure of CD34(+) cells from healthy individuals and M2b leukemia patients.
  • To determine if atomic force microscopy (AFM) can reveal differences in cell surface topography not discernible by optical microscopy.

Summary:

  • Bone marrow CD34(+) cells from normal subjects and M2b leukemia patients were analyzed using optical and atomic force microscopy (AFM).
  • While optical microscopy showed no significant differences, AFM revealed distinct surface roughness, with normal CD34(+) cells displaying a more rugged and erosive surface.

Related Experiment Videos

  • Leukemic CD34(+) cells exhibited a smoother surface topography compared to their normal counterparts.

    • Impact:

    • Atomic force microscopy (AFM) provides a higher resolution for characterizing cell surface differences in hematological malignancies.
    • The observed surface structural variations may correlate with functional or developmental differences between normal and leukemic CD34(+) cells.
    • This study contributes to the understanding of cellular changes in M2b leukemia at the nanoscale level.