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Updated: Aug 29, 2026
Intrasplenic Transplantation of Hepatocytes After Partial Hepatectomy in NOD.SCID Mice
Published on: February 10, 2018
[Comparative study of three local ablation methods for transplanted hepatocellular carcinoma in mice]
Wei-liang Zhu1, Jian Zhang, Ji-ren Zhang
1Department of Oncology, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China. duarion@sohu.com
Objective:
To observe the effects of three commonly used local ablation methods in the treatment of transplanted hepatocellular carcinoma in mice to provide experimental evidence for treating hepatocellular carcinoma that defies surgical removal.
Methods:
Mouse models of hepatocellular carcinoma were established by means of subcutaneous transplantation, and treatment results of the three ablation methods, namely percutaneous ethanol injection therapy (PEIT), percutaneous acetic acid injection therapy (PAIT) and percutaneous local cryosurgery therapy (PLCT), were compared.
Results:
The tumor inhibition rates of PLCT, PAIT and PEIT were 99.2%, 85.3%, and 72.8%, respectively. The rates for complete necrosis of the tumors were 100% (5/5), 60% (3/5), and 40% (2/5), with the survival time of 88.11+/-5.67, 86.67+/-7.26, and 72.89+/-12.86 days respectively.
Conclusions:
All of the three local ablation methods can inhibit the tumor growth to various degrees and prolong the survival time of the tumor-bearing mice. PLCT may yield relatively better result than the other two methods.
