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Published on: June 16, 2011
Defective activation-induced cell death in NOD T lymphocytes: 1,25-dihydroxyvitamin D3 restores defect
1Laboratorium voor Experimentele Geneeskunde en Endocrinologie (LEGENDO), Katholieke Universiteit Leuven, Leuven, Belgium.
Abstract:
The aim of this study was first to analyze strain differences in apoptosis resistance of NOD peripheral T lymphocytes in in vitro models of death by neglect and activation-induced cell death (AICD). Especially AICD is known to play a key role in peripheral tolerance, keeping autoimmune effector cells under control. Second, we studied the effects of in vivo treatment of NOD mice with 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)], an immunomodulator known to prevent diabetes and insulitis in NOD mice, on in vitro T lymphocyte apoptosis resistance.
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