Related Experiment Video
Updated: Jul 6, 2026

Generation and Isolation of Cell Cycle-arrested Cells with Complex Karyotypes
Published on: April 13, 2018
Tumbling down a different pathway to genetic instability
Haiwei H Guo1, Lawrence A Loeb
1Jospeh Gottstein Research Laboratory, Department of Pathology, University of Washington, Seattle 98195-7705, USA.
Abstract:
Ulcerative colitis (UC), a chronic inflammatory condition associated with a predisposition to colon cancer, is frequently characterized by DNA damage in the form of microsatellite instability (MSI). A new report links inflammation in UC with increases in the DNA repair enzymes 3-methyladenine DNA glycosylase and apurinic/apyrimidinic endonuclease, and, paradoxically, with increased MSI. These findings may represent a novel mechanism contributing to MSI in chronic inflammation.
Related Concept Videos
DNA Damage can Stall the Cell Cycle
Restarting Stalled Replication Forks
Cancers Originate from Somatic Mutations in a Single Cell
DNA Damage Can Stall the Cell Cycle
Cancers Originate from Somatic Mutations in a Single Cell
Spontaneous and Induced Mutations

