Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pediatric tuberculosis.

Ann M Loeffler1

  • 1Francis J Curry National Tuberculosis Center, University of California, San Francisco, CA, USA. aloeffle@lhs.org

Seminars in Respiratory Infections
|December 18, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of an Antimicrobial Stewardship Program on Antibiotic Use at a Nonfreestanding Children's Hospital.

Journal of the Pediatric Infectious Diseases Society·2017
Same author

Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2017
Same author

Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2016
Same author

Impact of standardization of antimicrobial prophylaxis duration in pediatric cardiac surgery.

The Journal of thoracic and cardiovascular surgery·2016
Same author

Pharmacokinetics and Dosing of Levofloxacin in Children Treated for Active or Latent Multidrug-resistant Tuberculosis, Federated States of Micronesia and Republic of the Marshall Islands.

The Pediatric infectious disease journal·2015
Same author

Diagnostic challenges of central nervous system tuberculosis.

Emerging infectious diseases·2008
Same journal

TB vaccines at the turn of the century: insights into immunity to M. tuberculosis and modern approaches for prevention of an ancient disease.

Seminars in respiratory infections·2003
Same journal

Environmental infection control of tuberculosis.

Seminars in respiratory infections·2003
Same journal

Mycobacterium tuberculosis: the treatment of active disease.

Seminars in respiratory infections·2003
Same journal

Clinical and radiographic features of HIV-related tuberculosis.

Seminars in respiratory infections·2003
Same journal

Treatment of latent tuberculosis infection.

Seminars in respiratory infections·2003
Same journal

The diagnosis of tuberculosis: what's old, what's new.

Seminars in respiratory infections·2003
See all related articles

Pediatric tuberculosis (TB) diagnosis and treatment present unique challenges in children, differing significantly from adult cases. However, children generally respond well to treatment and tolerate medications effectively.

Area of Science:

  • Pediatric Infectious Diseases
  • Mycobacterial Infections
  • Public Health

Background:

  • Pediatric tuberculosis (TB) diagnosis is complicated by non-specific symptoms and challenges in microbiological confirmation.
  • Children experience a higher incidence of extrapulmonary and disseminated TB compared to adults.
  • Treatment of pediatric TB is hindered by a lack of pediatric drug formulations and toxicity monitoring difficulties.

Purpose of the Study:

  • To outline the key differences in pediatric tuberculosis compared to adult tuberculosis.
  • To provide guidance on the diagnosis, treatment, and management of TB in children.
  • To emphasize the favorable outcomes and safety of TB treatment in pediatric populations.

Main Methods:

  • Review of clinical presentation, diagnostic challenges, and treatment strategies for pediatric TB.

Related Experiment Videos

  • Comparison of TB management in children versus adults, including latent TB infection.
  • Discussion of transmission dynamics and specific considerations for Mycobacterium bovis infection.

    • Main Results:

    • Pediatric TB requires distinct diagnostic approaches due to symptom variability and microbiological limitations.
    • Children with active TB are generally not contagious and acquire infections from adult or adolescent cases or contaminated milk.
    • Latent TB infection in children warrants treatment due to high risk of progression and long latency period.

    Conclusions:

    • Despite diagnostic and treatment challenges, pediatric TB generally has excellent outcomes with appropriate management.
    • Treatment regimens for children are similar to adults, with a four-drug approach recommended for presumed active TB with resistance risk.
    • Proactive treatment of latent TB infection in children is crucial due to their long-term risk of reactivation.