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Updated: Aug 10, 2026
Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
Published on: November 29, 2024
[Platelet activation marker]
1First Department of Internal Medicine, Kansai Medical University, Moriguchi 570-8507.
Insights
Diabetic patients show elevated platelet activation markers and platelet-derived microparticles (PDMP), contributing to atherosclerosis. These markers may help assess vascular damage in diabetes.
Area of Science:
- Cardiovascular Medicine
- Diabetology
- Hematology
Context:
- Atherosclerosis is a major cause of mortality in diabetes mellitus.
- Traditional risk factors do not fully explain the increased atherosclerosis incidence in diabetic patients.
- Diabetic platelets exhibit heightened aggregation sensitivity and elevated activation markers.
Purpose:
- To investigate the role of platelet activation markers and platelet-derived microparticles (PDMP) in diabetes-associated atherosclerosis.
- To explore the relationship between platelet activation, shear stress, and PDMP generation in diseased vasculature.
- To assess the utility of platelet activation markers in evaluating vascular damage in diabetic individuals.
Summary:
- Elevated platelet activation markers (CD62P, CD63, PAC-1, Annexin V) and PDMP are observed in diabetes.
- PDMP, expressing procoagulant phospholipids, are implicated in disease pathogenesis.
- High shear stress induces platelet aggregation and PDMP shedding, relevant to microvascular conditions.
- Platelet activation markers and PDMP may contribute to atherosclerosis development in diabetes.
Impact:
- Platelet activation markers may serve as valuable indicators for assessing vascular damage in diabetic patients.
- Understanding PDMP's role can inform strategies for managing atherosclerosis in diabetes.
- This research highlights the complex interplay between platelet function and cardiovascular complications in diabetes.
Abstract:
Atherosclerosis is the leading cause of death in patients with diabetes mellitus, increasing mortality in all forms of the disease. Classical risk factors, including hyperlipidemia, hypertension and obesity, do not completely account for the increased incidence of atherosclerosis in diabetes. Some platelet activation markers such as CD62P, CD63, PAC-1, Annexin V and platelet-derived microparticles (PDMP) are elevated in patients with diabetes, since diabetic platelets often have increased sensitivity to secondary aggregation in response to agonist. PDMPs are thought to play a role in clinical disease because they express phospholipids that function as procoagulants. High shear stress can initiate both platelet aggregation and shedding of procoagulant-containing PDMP, suggesting that PDMP generation by high shear stress occurs in small diseased arteries and arterioles under various clinical conditions. Platelet activation markers were significantly higher in the hypertensive or hyperlipidemic patients than in the controls. Selectins and cell adhesion molecules were also higher in the hypertensive or hyperlipidemic patients, and they were significantly higher in these patients with diabetes. Activated microparticles and PDMP may contribute to the development of atherosclerosis in diabetes, and platelet activation markers seem to be useful for the assessment of vascular damage in these patients.
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