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Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

819
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
819
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

314
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
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Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

710
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
710
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

401
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
401
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

284
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
284
Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

313
Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
313

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Related Experiment Video

Updated: Jun 28, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

[Thioredoxin and atherosclerosis].

Keisuke Shioji1, Hajime Nakamura

  • 1Department of Epidemiology, Research Institute, National Cardiovascular Center, Suita 565-8565.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|December 19, 2003
PubMed
Summary
This summary is machine-generated.

Thioredoxin (TRX) protects cells from stress and regulates cellular events. Elevated serum TRX levels indicate heart failure severity and are linked to cardiovascular diseases like atherosclerosis.

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Last Updated: Jun 28, 2026

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Quantification of Atherosclerosis in Mice
06:59

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Published on: June 12, 2019

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cardiovascular Research

Context:

  • Intracellular redox state modulation influences cellular events like proliferation and death.
  • Thioredoxin (TRX), a stress-inducible protein, scavenges reactive oxygen species (ROS) and regulates intracellular molecules.
  • TRX plays a role in cellular defense against oxidative stress.

Purpose:

  • To investigate the role of Thioredoxin (TRX) in cardiovascular diseases.
  • To assess serum TRX levels in patients with heart failure and acute coronary syndrome (ACS).
  • To examine TRX expression in atherosclerotic plaques and injured arteries.

Summary:

  • Overexpression of TRX in transgenic mice reduced adriamycin-induced cardiotoxicity.
  • Serum TRX levels correlated with heart failure severity and inversely with left ventricular ejection fraction.
  • Serum TRX levels were higher in ACS patients than stable angina (SA) patients, but not different from controls.
  • TRX expression was enhanced in human atherosclerotic plaques and balloon-injured rat arteries.

Impact:

  • TRX and its modulated redox system are crucial for cellular defense against oxidative stress in cardiovascular diseases.
  • Findings suggest TRX as a potential biomarker for heart failure and atherosclerosis.
  • Highlights the therapeutic potential of targeting the TRX system in cardiovascular disease treatment.