Peroxidative stress effects on calpain activity in brain of young and adult rats
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M Benuck1, M Banay-Schwartz, M T Ramacci
1N.S. Kline Institute for Psychiatric Research, Center for Neurochemistry, Orangeburg, NY 10962.
Brain Research
|November 20, 1992
Abstract:
Three hours after administration of the pro-oxidant 2-cyclohexen-1-one, calpain activity was significantly reduced in the brain of young rats, but not in the brain of adult rats, and cathepsin D activity remained unchanged. Addition of isovalerylcarnitine to the incubation medium increased calpain activity 5-7-fold, counteracting the effect of the pro-oxidant.