Related Experiment Video
Updated: Aug 29, 2026

Analysis of the Epithelial Damage Produced by Entamoeba histolytica Infection
Published on: June 12, 2014
Collagen-induced STAT family members activation in Entamoeba histolytica trophozoites
Jorge Cruz-Vera1, L Clara, R Hernández-Kelly
1Departamento de Genética y Biología Molecular, Cinvestav-IPN, Apartado Postal 14-740, México DF, 07300 México, Mexico.
Abstract:
The interaction of Entamoeba histolytica trophozoites with collagen type I and calcium induces a membrane to nuclei signaling. The transduction pathways involved in such phenomena are still poorly understood. Using a combination of immunoprecipitation assays, Western immunoblot analysis, electrophoretic mobility shift assays and immunocytochemistry we demonstrate here the expression, tyrosine phosphorylation, nuclear translocation and DNA binding of two members of the signal transducers and activators of transcription family of inducible transcription factors in the protozoan parasite E. histolytica. These results support the notion that the interaction of the extracellular matrix components with the parasite turns on a genetic program that facilitates the invasion of the host.
Related Concept Videos
Amebiasis
The JAK-STAT Signaling Pathway
Structural Protein Function
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to form...
Intracellular Signaling Affects Focal Adhesions
Some...

