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Glial localization of interleukin-1 alpha in invertebrate ganglia
L R Paemen1, E Porchet-Hennere, M Masson
1Multidisciplinary Center for the Study of Aging, State University of New York, Old Westbury 11568.
Cellular and Molecular Neurobiology
|October 11, 1992
Abstract:
1. Mytilus pedal ganglion contains a small population of glial cells that are immunopositive for interleukin-1 alpha. Positively stained fibers can also be seen in the neuropil of these sections. 2. The marine worm Nereis diversicolor also exhibits positive neural immunostaining for interleukin-1 alpha. 3. Both organisms contain hemocytes that contain immunoactivity for interleukin-1 alpha. The study suggests interleukin-1 alpha to be an ancient cytokine given its presence in organisms that evolved significantly earlier than mammals.