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GenBank: update.

Dennis A Benson1, Ilene Karsch-Mizrachi, David J Lipman

  • 1National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA.

Nucleic Acids Research
|December 19, 2003
PubMed
Summary
This summary is machine-generated.

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GenBank is a vital DNA sequence database for over 140,000 organisms, facilitating global research through daily updates and integrated analysis tools. It ensures worldwide coverage via data exchange with international DNA databases.

Area of Science:

  • Bioinformatics
  • Genomics
  • Molecular Biology

Background:

  • GenBank is a primary public repository for DNA sequences.
  • It houses data from over 140,000 named organisms.
  • Submissions originate from individual labs and large-scale sequencing initiatives.

Purpose of the Study:

  • To describe the GenBank database and its accessibility.
  • To highlight its role in scientific research and data sharing.
  • To provide information on accessing and utilizing GenBank resources.

Main Methods:

  • Data collection through laboratory and large-scale project submissions (BankIt, Sequin).
  • Maintenance of comprehensive DNA sequence records.
  • Daily data exchange with EMBL Data Library and DNA Data Bank of Japan for global coverage.

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Main Results:

  • GenBank provides access to over 140,000 named organism DNA sequences.
  • Integrated access via NCBI's Entrez system, linking sequences with other biological data.
  • Sequence similarity searches available through BLAST.

Conclusions:

  • GenBank is an essential, globally accessible resource for DNA sequence data.
  • Its integration with Entrez and tools like BLAST enhances biological research.
  • Regular updates and FTP access ensure data availability.