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Related Experiment Videos

ASD: the Alternative Splicing Database.

T A Thanaraj1, Stefan Stamm, Francis Clark

  • 1European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK. thanaraj@ebi.ac.uk

Nucleic Acids Research
|December 19, 2003
PubMed
Summary
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Alternative splicing generates diverse gene products crucial for development and disease. The Alternative Splicing Database (ASD) now offers curated data on splice events and regulatory mechanisms across nine species.

Area of Science:

  • Genomics
  • Molecular Biology
  • Bioinformatics

Background:

  • Alternative splicing is a key mechanism in mammalian gene expression, producing varied transcript isoforms.
  • Specific splice patterns are often linked to developmental stages, tissue types, or disease states.
  • Systematic data collection and annotation of alternative splicing events are essential.

Purpose of the Study:

  • To present two key products from the Alternative Splicing Database (ASD) consortium.
  • To provide a database of computationally identified alternative splice events.
  • To offer a database of alternatively spliced exons curated from scientific literature.

Main Methods:

  • Computationally delineating alternative splice events from EST/cDNA and genome sequence alignments.

Related Experiment Videos

  • Curating alternatively spliced exons from published scientific literature.
  • Annotating splice events with biological features such as expression states and cross-species conservation.

    • Main Results:

    • Development of a database detailing computationally identified alternative splice events across nine organisms.
    • Creation of a literature-derived database of alternatively spliced exons.
    • Annotation of splice events for biological context, including conservation and expression.

    Conclusions:

    • The ASD provides valuable, curated resources for studying alternative splicing.
    • These databases facilitate research into the biological roles and regulatory mechanisms of splice variants.
    • The ASD web pages serve as a central hub for accessing this critical data.