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Related Experiment Videos

Aptamer database.

Jennifer F Lee1, Jay R Hesselberth, Lauren Ancel Meyers

  • 1Department of Chemistry and Biochemistry, Institute for Cell and Molecular Biology, University of Texas at Austin, 1 University Station A4800, Austin, TX 78712, USA.

Nucleic Acids Research
|December 19, 2003
PubMed
Summary

This study introduces a comprehensive aptamer database, a valuable resource for diagnostic and therapeutic applications. It also aids theoretical biologists in exploring fitness landscapes of selected nucleic acid structures.

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Area of Science:

  • Biochemistry
  • Bioinformatics
  • Molecular Biology

Background:

  • Existing sequence databases like GenBank do not typically store data on aptamers and unnatural ribozymes.
  • Aptamers and unnatural ribozymes are generated using in vitro selection methods.
  • These molecules hold potential for diagnostic and therapeutic applications.

Purpose of the Study:

  • To create a centralized repository for aptamer and unnatural ribozyme sequences.
  • To provide a resource for researchers investigating the potential utility of these molecules.
  • To support theoretical biology by offering data for fitness landscape analysis.

Main Methods:

  • Compiling sequence information from in vitro selection experiments.
  • Organizing data for aptamers and unnatural ribozymes.

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  • Establishing a publicly accessible online database.

    • Main Results:

    • A comprehensive database of aptamer and unnatural ribozyme sequences has been established.
    • The database includes sequences generated via in vitro selection.
    • The resource is updated monthly.

    Conclusions:

    • The aptamer database serves as a crucial resource for both applied (diagnostic, therapeutic) and theoretical (fitness landscape) research.
    • It fills a gap in existing sequence data repositories.
    • The database is publicly available and regularly updated.