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Genew: the Human Gene Nomenclature Database, 2004 updates.
Hester M Wain1, Michael J Lush, Fabrice Ducluzeau
1HUGO Gene Nomenclature Committee (HGNC), Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK. nome@galton.ucl.ac.uk
Nucleic Acids Research
|December 19, 2003
Summary
The Human Gene Nomenclature Database (HGNC) provides approved human gene symbols. Recent improvements enhance data analysis and gene symbol request management for consortia.
Area of Science:
- Genetics
- Bioinformatics
Background:
- The Human Gene Nomenclature Database (Genew) is the sole resource for approved human gene symbols.
- Managed by the HUGO Gene Nomenclature Committee (HGNC), it contains over 22,000 records, with 75% publicly accessible online.
- The database operates confidentially, managing numerous gene symbol requests.
Purpose of the Study:
- To detail improvements in the Genew search engine since 2002.
- To highlight enhanced capacity for analyzing confidential sequence data.
- To demonstrate the ability to manage increasing gene symbol requests from sequencing consortia.
Main Methods:
- Systematic updates to the Genew search engine.
- Development of enhanced capabilities for confidential sequence data analysis.
- Streamlined processes for handling gene symbol requests.
Main Results:
- Significant enhancements to the Genew search engine functionality.
- Increased capacity for analyzing sensitive genetic sequence data.
- Efficient management of a large volume of gene symbol requests.
Conclusions:
- The HGNC's Genew database is crucial for standardized human gene nomenclature.
- Ongoing technical improvements ensure efficient data management and accessibility.
- The database effectively supports large-scale genomic research initiatives.