Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Organization of Genes

Organization of Genes

Genomics

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...

Organization of Genes

Organization of Genes

Cell Specific Gene Expression

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...

DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

Genome Annotation and Assembly

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Arthroscopic vs. open Broström-Gould procedure for chronic lateral ankle instability: a systematic review and meta-analysis.

Frontiers in surgery·2026

Same author

Polygenic risk score analysis of noise-induced hearing loss: An integrated cross-sectional and longitudinal study.

Hearing research·2026

Same author

Advances and Prospects of ZIF-Based Nanoplatforms for Therapeutic and Diagnosis Strategies in Endocrine Diseases.

ACS applied bio materials·2026

Same author

Sympathetic immunomodulation suppresses liver metastasis by maintaining the balance between norepinephrine concentration and the α2a/β2-AR ratio.

Cellular & molecular immunology·2026

Same author

AS1411 aptamer-functionalized, cell membrane-camouflaged nanoparticles for targeted tumor cells imaging in the Raman silent region.

Analytical and bioanalytical chemistry·2026

Same author

NRAC: an emerging nutrient-responsive regulator of tissue-specific fatty acid metabolism.

Biochemical and biophysical research communications·2026

Search research articles

Related Experiment Video

Updated: Jul 26, 2026

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

DEG: a database of essential genes.

Ren Zhang¹, Hong-Yu Ou, Chun-Ting Zhang

¹Department of Epidemiology and Biostatistics, Tianjin Cancer Institute and Hospital, Tianjin 300060, China.

Nucleic Acids Research

|December 19, 2003

Summary

Essential genes are vital for cellular life, forming a minimal gene set. The Database of Essential Genes (DEG) aids in identifying essential genes and potential antibacterial drug targets.

Area of Science:

Genomics
Molecular Biology
Bioinformatics

Background:

Essential genes are indispensable for cellular viability, representing a minimal gene set.
Understanding essential genes is fundamental to defining basic cellular functions and identifying drug targets.
The functions of essential genes are conserved across species, highlighting their foundational role in life.

Purpose of the Study:

To construct and present the Database of Essential Genes (DEG).
To provide a resource for identifying essential genes and their functions.
To facilitate research into the fundamental requirements of cellular life and potential therapeutic targets.

Main Methods:

Compilation of currently available essential gene data.
Development of a searchable database (DEG) for essential genes.

More Related Videos

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

Development of Compendium for Esophageal Squamous Cell Carcinoma

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

Related Experiment Videos

Last Updated: Jul 26, 2026

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

Development of Compendium for Esophageal Squamous Cell Carcinoma

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

Implementation of BLAST functionality for sequence homology searches against DEG.

Main Results:

Creation of the Database of Essential Genes (DEG).
DEG allows users to search essential genes by name or function.
Homology searches can predict potential essentiality of queried genes.

Conclusions:

Essential genes are critical for life and serve as potential targets for antibacterial drug development.
The DEG database provides a valuable resource for exploring fundamental cellular functions.
Analysis of essential genes contributes to understanding the core requirements for cellular existence.