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Updated: Aug 1, 2026
08:33
Labelling and Visualization of Mitochondrial Genome Expression Products in Baker's Yeast Saccharomyces cerevisiae
Published on: April 11, 2021
MitoP2, an integrated database on mitochondrial proteins in yeast and man
C Andreoli1, H Prokisch, K Hörtnagel
1Institute of Human Genetics, GSF National Research Center for Environment and Health, Neuherberg, Germany.
Nucleic Acids Research
|December 19, 2003
Summary
The MitoP2 database offers a curated list of mitochondrial proteins from yeast and humans. This resource integrates various data types to aid research into human mitochondriopathies.
Area of Science:
- Biochemistry
- Molecular Biology
- Bioinformatics
Background:
- Mitochondria are crucial organelles involved in cellular energy production and various metabolic pathways.
- Understanding the mitochondrial proteome is essential for deciphering cellular function and disease mechanisms.
- Existing resources for mitochondrial proteins were fragmented and lacked comprehensive integration.
Purpose of the Study:
- To create a centralized, annotated reference database of mitochondrial proteins from yeast and humans.
- To integrate diverse datasets relevant to mitochondrial proteome research.
- To facilitate the genetic characterization of human mitochondriopathies.
Main Methods:
- Literature review to establish an annotated reference set of yeast and human mitochondrial proteins.
- Integration of computational predictions (e.g., signaling sequences).
- Inclusion of data from proteome mapping, mutant screening, expression profiling, protein-protein interaction, and sublocalization studies.
Main Results:
- Development of the MitoP2 database (http://ihg.gsf.de/mitop2) as a comprehensive resource.
- Calculation of specificity and sensitivity for each data integration approach.
- Provision of evidence supporting mitochondrial candidate proteins.
Conclusions:
- The MitoP2 database serves as a valuable tool for researchers studying mitochondrial proteins.
- It facilitates the identification and genetic characterization of proteins involved in human mitochondriopathies.
- The integrated data and calculated metrics enhance the reliability of mitochondrial protein identification.
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