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ERGDB: Estrogen Responsive Genes Database.

Suisheng Tang1, Hao Han, Vladimir B Bajic

  • 1Knowledge Extraction Laboratory Institute for Infocomm Research, Singapore.

Nucleic Acids Research
|December 19, 2003
PubMed
Summary
This summary is machine-generated.

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The Estrogen Responsive Gene Database (ERGDB) consolidates information on genes affected by estrogen. It provides a centralized resource for researchers studying estrogen-regulated gene expression and experimental conditions.

Area of Science:

  • Molecular Biology
  • Genomics
  • Bioinformatics

Background:

  • Estrogen plays a crucial role in various biological processes.
  • Understanding estrogen-responsive genes is vital for numerous research areas.
  • Existing resources may lack comprehensive, curated data on estrogen-regulated genes.

Purpose of the Study:

  • To create an integrated knowledge database for estrogen-responsive genes.
  • To provide a unified platform for storing, searching, and retrieving information on these genes.
  • To offer detailed experimental context for estrogen-mediated gene regulation.

Main Methods:

  • Manual curation of gene information from PubMed publications by biologists.
  • Integration of data from multiple public databases (GenBank, LocusLink, Refseq, PubMed, ATCC).

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  • Development of a web interface for browsing and querying the database.

    • Main Results:

    • ERGDB contains experimentally validated estrogen-responsive genes.
    • Each record includes gene function, experimental conditions, and estrogen exposure details.
    • The database links to external genetic and literature resources.

    Conclusions:

    • ERGDB serves as a valuable, free resource for researchers studying estrogen's effects on gene expression.
    • The database facilitates in-depth analysis of estrogen-regulated genes and their experimental context.
    • It enhances the discoverability and accessibility of information on estrogen-responsive genes.