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Related Experiment Videos

Multiple bacteria in aortic aneurysms.

Rafael Marques da Silva1, Per S Lingaas, Odd Geiran

  • 1Institute of Oral Biology, Faculty of Dentistry, University of Oslo, PO Box 1052 Blindern, N-0316 Oslo, Norway. rafaels@odont.uio.no

Journal of Vascular Surgery
|December 19, 2003
PubMed
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Bacteria, particularly anaerobes, were found in over 26% of aortic aneurysm samples. These findings suggest microbial colonization may play a role in aneurysm development or progression.

Area of Science:

  • Microbiology
  • Vascular Surgery
  • Infectious Diseases

Background:

  • Aortic aneurysms are a significant cause of morbidity and mortality.
  • The role of microbial infection in the pathogenesis of aortic aneurysms remains debated.
  • Previous studies have yielded conflicting results regarding bacterial presence in aneurysmal tissue.

Purpose of the Study:

  • To investigate the presence of bacteria, with a focus on anaerobic species, within aortic aneurysm walls.
  • To characterize the types of bacteria identified in aneurysm samples.
  • To correlate microbiological findings with imaging and clinical data.

Main Methods:

  • Collection of 53 aneurysm wall samples from 49 patients undergoing surgery.
  • Anaerobic cultivation of tissue specimens.

Related Experiment Videos

  • Scanning and transmission electron microscopy (SEM/TEM) of 28 samples.
  • Identification of bacterial species using standard microbiological techniques.

    • Main Results:

    • Bacteria were detected in 26.4% of samples via anaerobic culture.
    • Anaerobic bacteria were identified in 71% of positive cultures, including Propionibacterium and Actinomyces species.
    • Electron microscopy revealed bacteria in 71% of examined samples, often associated with plaque.
    • Mixed bacterial infections (aerobic and anaerobic) were observed in some cases.

    Conclusions:

    • Aortic aneurysms are frequently colonized by diverse bacteria, including anaerobes not typically found on skin.
    • The presence of bacteria may contribute to aneurysm wall weakening through inflammation.
    • Further research is needed to determine if bacteria are primary pathogens or secondary colonizers in aortic aneurysms.