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Intracerebral inflammatory pseudotumour in a 16-month-old boy
S Radi-Bencteux1, F Proust, J-P Vannier
1Department of Neonatalogy and Intensive Care, Rouen University Hospital, Rouen, France. Sophie.Radi-Bencteux@chu-rouen.fr
Abstract:
A 16-month-old boy presenting with a previous two-month history of absences, was admitted for partial seizures and vomiting. Magnetic resonance imaging revealed a left temporo-occipital intraparenchymatous, well circumscribed lesion. Complete macroscopic resection was performed. Morphological and immunohistochemical analyses were conclusive for an inflammatory pseudotumour. Only a few cases of intracranial locations of this entity have been reported. Our case is the first described in an infant younger than four years of age. This observation suggests that chronic evolution may start earlier than thought in adult cases, perhaps due to an autoimmune process.
Insights
This study reports the first case of inflammatory pseudotumor in an infant, presenting with seizures and vomiting. Early chronic evolution may be linked to autoimmune processes.
Area of Science:
- Pediatric Neurology
- Neuro-oncology
- Pediatric Pathology
Background:
- Intracranial inflammatory pseudotumors are rare, with limited reported cases.
- Diagnosis often relies on advanced imaging and histopathological analysis.
Observation:
- A 16-month-old boy presented with absence seizures, partial seizures, and vomiting.
- MRI revealed a left temporo-occipital intraparenchymatous lesion.
- Complete surgical resection was performed.
Findings:
- Morphological and immunohistochemical analyses confirmed an inflammatory pseudotumor.
- This is the first reported case in an infant under four years old.
- The case suggests potential for earlier chronic evolution than previously observed in adults.
Implications:
- Highlights the possibility of inflammatory pseudotumors presenting in early infancy.
- Suggests a potential autoimmune etiology for chronic evolution of these lesions.
- Expands the known age spectrum for intracranial inflammatory pseudotumors.
