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[Structural and functional state of microsomal membranes in the rat brain cortex during long-term ethanol
1Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine.
Abstract:
The range of the Na+, K(+)-ATPase functional stability in microsomal fraction of rat brain cortex under long-term chronic ethanol (15%, v/v) consumption was ascertained. The enzyme activity decreased only after 15 months of alcoholisation on the background of the stable structural membrane characteristics (on the basis of the intrinsic and 1-anilinonaphthalene-8-sulfonate fluorescence parameters) and SH-content in postmitochondrial supernatant. The cellular homeostatic mechanisms under ethanol effect are discussed.
