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Updated: Aug 12, 2026

In vitro Enrichment of Ovarian Cancer Tumor-initiating Cells
11:37

In vitro Enrichment of Ovarian Cancer Tumor-initiating Cells

Published on: February 18, 2015

Ovarian tumors of low malignant potential

Cornelia Liu Trimble1, Edward L Trimble

  • 1Departments of Gynecology, Obstetrics, and Oncology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.

Oncology (Williston Park, N.Y.)
|December 20, 2003
PubMed

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...