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Updated: Aug 29, 2026

Determination of the Gas-phase Acidities of Oligopeptides
Published on: June 24, 2013
Acid-base equilibria in nonpolar media. 4. Extension of the self-consistent basicity scale in THF medium. Gas-phase
Ivari Kaljurand1, Toomas Rodima, Aino Pihl
1Department of Chemistry, University of Tartu, Jakobi 2, 51014 Tartu, Estonia.
Abstract:
Eleven new phenyl-substituted phosphazenes (P1-, P3-, and P4-bases) have been synthesized by the Staudinger or the Kirsanov reactions. The UV-vis spectrophotometric titration method was used to establish the relative basicity of them, and to extend the ion-pair basicity scale for THF medium. These measurements together with our previous work give a continuous basicity scale in THF ranging from 2.6 (2-MeO-pyridine) to 26.6 (2-Cl-C6H4P4(pyrr) phosphazene) in pKalpha units: that is for 24 orders of magnitude and containing 58 compounds (pyridines, anilines, amines, guanidines, amidines, phosphazenes). Ion-pair formation was taken into account by using the Fuoss equation. DeltapKip values of some phosphazene indicators estimated earlier by the 13C NMR method were revised. For some of the phosphazenes gas-phase basicities were measured.
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