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Updated: Jul 19, 2026

On-chip Isotachophoresis for Separation of Ions and Purification of Nucleic Acids
Published on: March 2, 2012
Triton X-100 enhances ion-pair-driven molecular recognition in aqueous media. Further work on a chemosensor for
Kenichi Niikura1, Eric V Anslyn
1Department of Chemistry and Biochemistry, The University of Texas, Austin, Texas 78712, USA.
Abstract:
Molecular recognition in water based on ion-pairing is hampered by competition from the solvent. We have reported that synthetic receptor 1 recognizes inositol trisphosphate (IP3) with a binding constant of 10(8) M(-1) in methanol. In this paper, instead of working in methanol, we report that the surfactant Triton-X 100 also yields a large absorbance or fluorescence change and a binding constant on the order of 10(6) M(-1).
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